Phytochemical Analysis and in vivo Hepatoprotective potential of Ipomoea eriocarpa R.Br.
Abstract
The present study investigate the phytochemicals of ethanolic extract of Ipomoea eriocarpa and hepatoprotective potential in vivo against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats as animal model at the doses of 100 mg/kg and 200 mg/kg body weight. The phytochemical analysis revealed that flavonoids, tannins and terpenoids were strongly present in plant extract. An oral dose plant extract of 100mg/kg body weight was identified from toxicity test and administered to albino mi
ce. The results showed that ethanolic extract of I. eriocarpa at the doses of 100 mg/kg and 200 mg/kg produced significant (p<0.05) decreases in paracetamol induced increased levels of liver serum enzymes such as ALT (alanine aminotransferase), AST (aspertase amino transferase), ALP (alkaline phosphatase), LDH (lactate dehydrogenase) and Total bilirubin and Total protein. The biochemical results of extract and toxic groups were also compared with standard drug silymarine. So the present study showed that methanolic extract of C. pendulus possessed hepatoprotective activity and it is a good antioxidant source. It is concluded that ethanolic plant extract have strong potential for antioxidant and hepatotoxicity and also proved themselves as strong therapeutic and remedial agent against human and animal disease